Afflictions in Pillars of Eternity 2: Deadfire are negative Status Effects that can affect characters within the game. Afflictions are explicitly bundled sets of status effects that can be applied to, suspended, or fully removed from a character. While some afflictions have explicit overriding or exclusivity rules, most afflictions can co-exist with other afflictions.
When a spell is cast on a target, it and its subordinate effects and afflictions are all bundled together in a procedurally-bundled container created by the spell.
If these procedurally-bundled containers are applied while an identical version is in effect (e.g. Blessing cast on someone already under the effect of a Blessing), the new version replaces the old.
No matter how many effects are on the target, generally only the best bonuses and the worst penalties are applied.
Afflictions are grouped by the corresponding Attribute which is affected. So, Affliction targeting a particular Attribute can be countered by a corresponding Inspiration, which also grants immunity against Afflictions of that type (for example, Constitution affliction like Sickened can be countered by Fit Inspiration).
Some creatures can be immune to one or more afflictions. If so, these afflictions cannot be applied to those creatures. If a creature has Resistance against Afflictions of some type, then incoming Affliction of that type will be downgraded in power and the weakest Affliction of that type will not be applied at all. Similarly, if a creature has Weakness against Afflictions of some type, then incoming Affliction of that type will be one tier higher.
Relative strength of Afflictions:
Might Afflictions: Stunned > Dazed > Staggered
Constitution Afflictions: Enfeebled > Weakened > Sickened
Dexterity Afflictions: Paralyzed > Immobilized > Hobbled
Perception Afflictions: Blinded > Disoriented > Distracted
Intellect Afflictions: Dominated > Charmed > Confused
Resolve Afflictions: Terrified > Frightened > Shaken
A Sickened character has -5 Constitution and all incoming healing is reduced by 25%.
Weakened characters have -5 Constitution and all incoming healing is reduced by half.
Enfeebled characters have -5 Constitution, cannot be healed, and all hostile effects applied to them last 50% longer.
Immobilized characters can't move and have -5 Dexterity.
Blinded characters suffer -5 Perception, are considered Flanked, have +50% Recovery after their actions, -10 Accuracy, and the distance of all their ranged attacks is halved. Also cannot use or be affected by Gaze attacks.
Confused characters are -5 Intellect and all of their abilties and attacks are friend or foe.
A Charmed character fights for their former enemies, but will only use basic attacks, no abilities. -5 Intellect.
A Dominated target is subservient to the will of the enemy and will use everything at its disposal to fight its former teammates. -5 Intellect.
Other combat status effects
A Petrified character's soul temporarily transforms their body into immobile, brittle stone. They suffer the same effects as being Paralyzed.
Injuries are long-term afflictions. "Long-term" means they last until the character rests and consumes Food. Injuries are typically gained through scripted interactions or by being Knocked Out in combat. If a character has three Injuries and would receive another, they are Killed.
Effects: -5 Fortitude, -3 Corrode Armor Rating
Characters with Bruised Ribs suffer a penalty to their Constitution.
Effects: -20 Fortitude
Fatigue represents the physical and psychological wear and tear of demanding activity on a character.
Effects: -5 Fortutude, -3 Freeze Armor Rating
Effects: -25% Healing received, -15% Max Health
Effects: -2 Dexterity, -3 Burn Armor Rating
The Sprained Wrist injury inflicts a penalty to Deflection.
Characters with a Swollen Eye suffer penalties to Perception.
Effects: -2 Perception, -3 Shock Armor Rating
A Twisted Ankle injury reduces a character's Reflex defense.
Characters with a Wrenched Knee suffer a penalty to Movement.
Effects: -25% Stride
Wrenched Shoulders inflict a penalty to Action Speed and Might.